RAF Typhoon fighter aircraft have operated alongside French aircraft in a combined operation against an subterranean weapons facility in Syrian territory operated by the IS group, according to the British defence ministry.
The site, located using surveillance, was assessed as storing arms and explosives, the release indicated, and was located in hills just above the historic site of Palmyra in central Syria.
"Our aircraft used laser-guided Paveway IV weapons to hit a number of approach shafts down to the depot... preliminary assessments suggest the objective was successfully hit," the ministry announced.
There was no indication of any harm to civilians in the attack on Saturday evening and every plane involved returned safely, the MoD added.
The Typhoon FGR4s were assisted by a Voyager tanker plane.
The Islamic State group - alternatively referred to as Daesh - established militant control over large swathes of both Syria and Iraq before its territorial defeat in 2019.
"This strike shows our UK leadership, and determination to work closely with our allies, to stamp out any revival of the terrorist group and their violent and radical beliefs in the region," Britain's Defence Chief the Defence Secretary said.
British military aircraft have performed patrols over Syria to "prevent any efforts to regroup" of the group following its military defeat at the climactic battle in Baghuz in 2019, the MoD reported.
"I extend gratitude to every member of British forces who took part in this strike for their skill and their bravery," Healey said. "They were among a great many British troops on duty over the holidays. This mission, to remove terrorist threats who endanger our security, demonstrates how UK forces are always on standby, throughout the year, keeping Britain secure within its borders and powerful internationally."
Last December, the American forces carried out what it called a "large-scale strike" on Islamic State objectives in the country, subsequent to an attack resulted in the deaths of two US servicemembers and a civilian interpreter in Palmyra.
The U.N. says Daesh still maintains between 5,000 and 7,000 fighters in Syria and Iraq.